Role of PKC isoforms in the FcγR‐mediated inhibition of LPS‐stimulated IL‐12 secretion by macrophages

  title={Role of PKC isoforms in the Fc$\gamma$R‐mediated inhibition of LPS‐stimulated IL‐12 secretion by macrophages},
  author={Van Fronhofer and Michelle R. Lennartz and Daniel J. Loegering},
  journal={Journal of Leukocyte Biology},
Ligation of Fc receptors for immunoglobulin G (FcγRs) inhibits lipopolysaccharide (LPS)‐stimulated secretion of interleukin (IL)‐12 by macrophages. FcγR activation of protein kinase C (PKC) contributes to several functions of this receptor including phagocytosis, activation of the reduced nicotinamide adenine dinucleotide phosphate oxidase, and secretion of certain cytokines. Therefore, we tested the hypothesis that PKC mediates the FcγR inhibition of IL‐12 secretion by macrophages. In murine… 

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