Role of PKA as a negative regulator of PCP signaling pathway during Xenopus gastrulation movements.

@article{Park2006RoleOP,
  title={Role of PKA as a negative regulator of PCP signaling pathway during Xenopus gastrulation movements.},
  author={Eunjoo Park and Gun-Hwa Kim and S C Choi and Jin-Kwan Han},
  journal={Developmental biology},
  year={2006},
  volume={292 2},
  pages={344-57}
}
Convergent extension (CE) movements in gastrulation are essential for the establishment of the body axis during early vertebrate development. Although the precise molecular mechanisms of CE movements are not clearly understood, noncanonical Wnt pathway is known to be important for the control of CE movements. Here, we present evidence that PKA is implicated in noncanonical Wnt pathway. Overexpression and specific depletion of PKA inhibit CE movements. PKA depletion also disrupts cell morphology… CONTINUE READING