Role of PI3K signaling in survival and progression of LNCaP prostate cancer cells to the androgen refractory state.

@article{Murillo2001RoleOP,
  title={Role of PI3K signaling in survival and progression of LNCaP prostate cancer cells to the androgen refractory state.},
  author={Horacio Murillo and Haojie Huang and L. J. Schmidt and David I. Smith and Donald J. Tindall},
  journal={Endocrinology},
  year={2001},
  volume={142 11},
  pages={4795-805}
}
The mechanisms by which prostate cancer (PCa) cells progress to a hormone refractory state are poorly understood. The progression process under androgen ablation conditions involves the survival of at least a portion of malignant cells and their eventual proliferation in an androgen-independent manner. The goal of this study was to investigate the role of PI3K signaling in such a progression. Using an in vitro model of androgen ablation, we show that after removal of androgen support, the human… CONTINUE READING

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