Role of PI3-kinase in the development of interstitial cells and pacemaking in murine gastrointestinal smooth muscle.

@article{Ward1999RoleOP,
  title={Role of PI3-kinase in the development of interstitial cells and pacemaking in murine gastrointestinal smooth muscle.},
  author={Sean M Ward and Murray F. Brennan and Vivienne Margaret Jackson and Kenton M. Sanders},
  journal={The Journal of physiology},
  year={1999},
  volume={516 ( Pt 3)},
  pages={835-46}
}
1. Development of the pacemaker system in the small intestine depends upon signalling via tyrosine kinase (Kit) receptors. The downstream pathways initiated by Kit in interstitial cells of Cajal (ICC) have not been investigated. Wortmannin and 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY 294002), inhibitors of phosphatidylinositol 3'-kinase (PI3-kinase), were used to test the involvement of this pathway in the development and maintenance of ICC and electrical rhythmicity in the murine… CONTINUE READING

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