Role of PGE2 in the colonic motility: PGE2 generates and enhances spontaneous contractions of longitudinal smooth muscle in the rat colon

@article{Iizuka2013RoleOP,
  title={Role of PGE2 in the colonic motility: PGE2 generates and enhances spontaneous contractions of longitudinal smooth muscle in the rat colon},
  author={Yumiko Iizuka and Atsukazu Kuwahara and Shin-ichiro Karaki},
  journal={The Journal of Physiological Sciences},
  year={2013},
  volume={64},
  pages={85-96}
}
The aim of this study was to determine which PGE2 receptors (EP1–4 receptors) influence colonic motility. Mucosa-free longitudinal smooth muscle strips of the rat middle colon spontaneously induced frequent phasic contractions (giant contractions, GCs) in vitro, and the GCs were almost completely abolished by a cyclooxygenase inhibitor, piroxicam, and by an EP3 receptor antagonist, ONO-AE3-240, but enhanced by tetrodotoxin (TTX). In the presence of piroxicam, exogenous PGE2, both ONO-AE-248… CONTINUE READING
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