Role of PAR2 in murine pulmonary pseudomonal infection.

  title={Role of PAR2 in murine pulmonary pseudomonal infection.},
  author={Theo J Moraes and Raiza Martin and Jonathan D Plumb and Eric Vachon and Cheryl M. Cameron and Ali Danesh and David Joseph Kelvin and Wolfram Ruf and Gregory P Downey},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  volume={294 2},
Proteinases can influence lung inflammation by various mechanisms, including via cleavage and activation of protease-activated receptors (PAR) such as PAR2. In addition, proteinases such as neutrophil and/or Pseudomonas-derived elastase can disarm PAR2 resulting in loss of PAR2 signaling. Currently, the role of PAR2 in host defense against bacterial infection is not known. Using a murine model of acute Pseudomonas aeruginosa pneumonia, we examined differences in the pulmonary inflammatory… CONTINUE READING


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Differential expression and regulation of protease-activated L375 PAR2 AND PSEUDOMONAS AJP-Lung Cell Mol Physiol

  • R Colognato, JR Slupsky, M Jendrach, L Burysek, T Syrovets, T. Simmet
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