Role of PAF Receptor in Proinflammatory Cytokine Expression in the Dorsal Root Ganglion and Tactile Allodynia in a Rodent Model of Neuropathic Pain

@inproceedings{Hasegawa2010RoleOP,
  title={Role of PAF Receptor in Proinflammatory Cytokine Expression in the Dorsal Root Ganglion and Tactile Allodynia in a Rodent Model of Neuropathic Pain},
  author={Shigeo Hasegawa and Yuta Kohro and Miho Shiratori and Satoshi Ishii and Takao Shimizu and Makoto Tsuda and Kazuhide Inoue},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND Neuropathic pain is a highly debilitating chronic pain following damage to peripheral sensory neurons and is often resistant to all treatments currently available, including opioids. We have previously shown that peripheral nerve injury induces activation of cytosolic phospholipase A(2) (cPLA(2)) in injured dorsal root ganglion (DRG) neurons that contribute to tactile allodynia, a hallmark of neuropathic pain. However, lipid mediators downstream of cPLA(2) activation to produce… CONTINUE READING

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