Role of P2X7R in the development and progression of pulmonary hypertension

@article{Yin2017RoleOP,
  title={Role of P2X7R in the development and progression of pulmonary hypertension},
  author={Jie Yin and Shuling You and Haopeng Liu and L. Chen and C. Zhang and Hesheng Hu and Mei Xue and Wen-juan Cheng and Ye Wang and Xinran Li and Yugen Shi and N. Li and Suhua Yan and Xiaolu Li},
  journal={Respiratory Research},
  year={2017},
  volume={18}
}
BackgroundPulmonary arterial hypertension (PAH) is a devastating disease that lacks sufficient treatment. Studies have shown that the Nod-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome contributes to PAH pathogenesis, but the role of the upstream molecular P2X7 receptor (P2X7R) has remained unexplored. We investigated the role of P2X7R in the pathogenesis of PAH.Methods and resultsPH was induced by a single subcutaneous injection of monocrotaline (MCT) (60 mg/kg) on left… Expand
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