Role of P2X7 receptors in ischemic and excitotoxic brain injury in vivo.

@article{Feuvre2003RoleOP,
  title={Role of P2X7 receptors in ischemic and excitotoxic brain injury in vivo.},
  author={Rosalind A Le Feuvre and David Brough and Omar Touzani and Nancy J. Rothwell},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2003},
  volume={23 3},
  pages={381-4}
}
Purinergic P2X7 receptors may affect neuronal cell death through their ability to regulate the processing and release of interleukin-1beta (IL-1beta), a key mediator in neurodegeneration. The authors tested the hypothesis that ATP, acting at P2X7 receptors, contributes to experimentally induced neuronal death in rodents in vivo. Deletion of P2X7 receptors (P2X7 knockout mice) did not affect cell death induced by temporary cerebral ischemia, which was reduced by treatment with IL-1 receptor… CONTINUE READING

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