Role of P-glycoprotein in distribution of rhodamine 123 into aqueous humor in rabbits.

@article{Kajikawa1999RoleOP,
  title={Role of P-glycoprotein in distribution of rhodamine 123 into aqueous humor in rabbits.},
  author={Tsuneo Kajikawa and Hiromu K. Mishima and Tadahiro Murakami and Makoto Takano},
  journal={Current eye research},
  year={1999},
  volume={18 3},
  pages={240-6}
}
PURPOSE Examination of the contribution of functional P-glycoprotein (P-gp), an ATP-dependent efflux pump, in blood-aqueous barrier in rabbits. METHODS Rhodamine-123 (Rho-123), a P-gp substrate, was administered intravenously via the marginal ear vein of rabbits. Rhodamine B (Rho-B), an analogue of Rho-123, was also injected with the same dose, as a reference compound. Quinidine at different concentrations was applied topically to the corneal surface by eye drops prior to the intravenous… CONTINUE READING

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