Role of OxyS of Mycobacterium tuberculosis in oxidative stress: overexpression confers increased sensitivity to organic hydroperoxides.

@article{Domenech2001RoleOO,
  title={Role of OxyS of Mycobacterium tuberculosis in oxidative stress: overexpression confers increased sensitivity to organic hydroperoxides.},
  author={Pilar Domenech and Nadine Honor{\'e} and B{\'e}ate Heym and Stewart T Cole},
  journal={Microbes and infection},
  year={2001},
  volume={3 9},
  pages={713-21}
}
Mycobacterial genomics has uncovered a novel regulatory gene, oxyS, belonging to the LysR family. There is extensive similarity in the DNA-binding domain of OxyS with that of OxyR, the oxidative stress response protein of many bacteria. Since the oxyR gene of Mycobacterium tuberculosis has been multiply inactivated during evolution it was conceivable that some of its functions could be effected by OxyS. It is shown here that OxyS is produced at low levels and that there are at least three… CONTINUE READING

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