Role of Organic Anion Transporters in the Uptake of Protein-Bound Uremic Toxins by Human Endothelial Cells and Monocyte Chemoattractant Protein-1 Expression.

@article{Favretto2017RoleOO,
  title={Role of Organic Anion Transporters in the Uptake of Protein-Bound Uremic Toxins by Human Endothelial Cells and Monocyte Chemoattractant Protein-1 Expression.},
  author={Giane Favretto and Lauro M Souza and Paulo C Greg{\'o}rio and Regiane S Cunha and Rayana Ariane Pereira Maciel and Guilherme Lanzi Sassaki and Maria Lu{\'i}za G. de Toledo and Roberto Fl{\'a}vio Silva Pecoits-Filho and Wesley Mauricio de Souza and Andr{\'e}a Emilia Marques Stinghen},
  journal={Journal of vascular research},
  year={2017},
  volume={54 3},
  pages={
          170-179
        }
}
Organic anion transporters (OATs) are involved in the uptake of uremic toxins such as p-cresyl sulfate (PCS) and indoxyl sulfate (IS), which play a role in endothelial dysfunction in patients with chronic kidney diseases (CKD). In this study, we investigated the role of OAT1 and OAT3 in the uptake of PCS and IS into human endothelial cells. PCS was… CONTINUE READING