Role of Oct4 in maintaining and regaining stem cell pluripotency

  title={Role of Oct4 in maintaining and regaining stem cell pluripotency},
  author={Guilai Shi and Ying Jin},
  booktitle={Stem Cell Research & Therapy},
Pluripotency, a characteristic of cells in the inner cell mass of the mammalian preimplantation blastocyst as well as of embryonic stem cells, is defined as the ability of a cell to generate all of the cell types of an organism. A group of transcription factors is essential for the establishment and maintenance of the pluripotent state. Recent studies have demonstrated that differentiated somatic cells could be reverted to a pluripotent state by the overexpression of a set of transcription… CONTINUE READING
42 Extracted Citations
76 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 42 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 76 references

A mesenchymaltoepithelial transition initiates and is required for the nuclear reprogramming of mouse fi broblasts

  • M Abu-Remaileh, A Gerson, +6 authors Y Bergman
  • Cell Stem Cell
  • 2010

Hooking up with Oct 4

  • DA Card, PB Hebbar, +4 authors TK Archer
  • Cell Stem Cell
  • 2010

The nuclear receptor Nr 5 a 2 can replace Oct 4 in the reprogramming of murine somatic cells to pluripotent cells

  • M Wernig, A Meissner, +5 authors R Jaenisch
  • Cell Stem Cell
  • 2010

A genomescale RNAi screen for Oct 4 modulators defi nes a role of the Paf 1 complex for embryonic stem cell identity

  • L Ding, M Paszkowski-Rogacz, +19 authors F Buchholz
  • Cell Stem Cell
  • 2009

Similar Papers

Loading similar papers…