Role of OGR1 in myeloid-derived cells in prostate cancer

  title={Role of OGR1 in myeloid-derived cells in prostate cancer},
  author={Libo Yan and Lisam Shanjukumar Singh and Li Zhang and Y Xu},
Ovarian cancer G-protein-coupled-receptor-1 (OGR1) is a tumor metastasis suppressor in prostate cancer (PCa). OGR1 knockout mice (ogr1−/−) are grossly normal under physiological conditions, however, reduced melanoma tumorigenesis has been observed, with the mechanisms of this reduction completely unknown. In this work, we demonstrated that OGR1 deficiency in host cells significantly reduced tumorigenesis of PCa in mice. Adoptive transfer of WT CD11b+ Gr1+ double positive (DP) cells, but not T… CONTINUE READING
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