Role of Notch signaling in colorectal cancer.

  title={Role of Notch signaling in colorectal cancer.},
  author={Liang Qiao and Benjamin Chun-Yu Wong},
  volume={30 12},
  • L. Qiao, B. Wong
  • Published 1 December 2009
  • Biology, Chemistry
  • Carcinogenesis
Notch signaling is an important molecular pathway involved in the determination of cell fate. In recent years, this signaling has been frequently reported to play a critical role in maintaining progenitor/stem cell population as well as a balance between cell proliferation, differentiation and apoptosis. Thus, Notch signaling may be mechanistically involved carcinogenesis. Indeed, many studies have showed that Notch signaling is overexpressed or constitutively activated in many cancers… 

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Notch signaling and intestinal cancer.
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This chapter reviews the current understanding and research findings of the role of Notch signaling in intestinal homeostasis and colorectal cancer and discusses the possible Notch targeting approaches as novel molecular therapy for intestinal cancer.
Targeting Notch Signaling in Colorectal Cancer
The importance of Notch as a preventive and therapeutic target for colon cancer and on the effect of WA on this signaling pathway in the context of colon cancer are focused on.
Role of Notch Signaling in Colorectal Cancer
In CRC Notch promotes the stemness and epithelial to mesenchymal transition (EMT) which are requiring in aberrant crypt formation, invasion, and metastasis, respectively, and overexpression of Notch in CRC is connected with poor prognosis and chemoresistance.
Association between Notch signaling pathway and cancer
Recently published data concerning the role of the Notch signaling pathway components in development and prognosis of oncologic diseases, in occurrence of resistance to cytostatic agents and importance in creating of new cancer treatment approaches are presented.
Signaling pathways involved in colorectal cancer progression
This review will focus on the mitogen-activated protein kinase (MAPK) cascades downstream of the epidermal growth factor receptor (EGFR), Notch, PI3K/AKT pathway, transforming growth factor-β (TGF-β), and Wnt signaling pathways.
A Review on Notch Signaling and Colorectal Cancer
Colorectal cancer (CRC) has one of the highest mortality rates despite the advancement of treatment options. Aggressive CRC remains difficult to treat owing to the activation of oncogenic signaling
Cancer Stem Cells, Quo Vadis? The Notch Signaling Pathway in Tumor Initiation and Progression
An overview of the activity of Notch signaling in a variety of tumors is provided, focusing mostly on its role in the maintenance of the undifferentiated subset of cancer cells.
Inflammation and Notch signaling: a crosstalk with opposite effects on tumorigenesis
The hypothesis that specific inflammatory conditions can control the activation of the Notch pathway in terms of biological effect is analyzed, partially explaining the dichotomy of both phenomena.
Notch1-dependent regulation of p27 determines cell fate in colorectal cancer.
It is demonstrated that in colorectal carcinoma cells the Notch1-dependent activation of cell cycle and proliferation is mediated by repression of the cyclin-dependent kinase inhibitor (CDKI) p27, and the half-life of p27 significantly increased after siRNA‑mediated knockdown of notch1.
Notch signaling pathway: architecture, disease, and therapeutics
This review focuses on both classical and the latest findings related to NOTCH signaling to illustrate the history, architecture, regulatory mechanisms, contributions to physiological development, related diseases, and therapeutic applications of the NOTCH pathway.


Recent insights into the role of Notch signaling in tumorigenesis.
This review highlights recent findings regarding the molecular and functional aspects of Notch-mediated neoplastic transformation and cellular mechanisms that potentially explain the complex role of notch in tumorigenesis.
Notch Signaling, γ-Secretase Inhibitors, and Cancer Therapy: Figure 1.
The biological roles of Notch molecules in cancer development are summarized with special emphasis on the promise and challenges in applying gamma-secretase inhibitors as a new line of targeted therapeutic agents.
Aberrant Activation of Notch Signaling in Human Breast Cancer
It is shown that increased RBP-Jkappa-dependent Notch signaling is sufficient to transform normal breast epithelial cells and that the mechanism of transformation is most likely through the suppression of apoptosis, suggesting that inhibition of notch signaling may be a therapeutic strategy for this disease.
The multifaceted role of Notch in cancer.
Alterations in Notch signaling in neoplastic lesions of the human cervix.
The evidence suggests that Notch expression is associated with cell populations that are undergoing cell fate changes and that notch activity can be used to monitor cell fate abnormalities in cervical as well as other epithelial neoplasias.
Activation of Notch signaling in human colon adenocarcinoma.
In situ hybridization is used to analyze expression of Notch ligands, receptors and fringe genes, as well as the Notch target gene, HES1, in human colorectal cancer (CRC), to establish that JAG ligands and NOTCH1, aswell as Notch receptor activation are consistent features of human CRC and support the notion that many of these tumors may respond to anti-Notch therapeutic regimes.
NOTCH signaling as a novel cancer therapeutic target.
The evidence linking NOTCH signaling to several types of cancer, as well as the possible therapeutic indications of NOTCH inhibitors and the challenges facing their clinical development are summarized.
Gamma-secretase inhibitor prevents Notch3 activation and reduces proliferation in human lung cancers.
The ability of MRK-003, a gamma-secretase inhibitor, to inhibit Notch3 signaling, growth, and apoptosis of lung cancer cell lines in vitro and in vivo is determined using mouse xenograft models.
Notch signaling as a therapeutic target in cancer: a new approach to the development of cell fate modifying agents
The most recent preclinical and clinical evidence linking Notch signaling to cancer is summarized, questions that remain unanswered are delineated and potential biopharmacological strategies to manipulate notch signaling in vivo are explored.
Cross-Talk Between Notch and EGFR Signaling in Human Breast Cancer Cells
Overexpression of Notch1 could reverse EGFR inhibitor–induced cell toxicity, suggesting that Notch and EGFR signaling may be positively cross-linked in human breast cancer.