Role of Notch signaling in colorectal cancer.

@article{Qiao2009RoleON,
  title={Role of Notch signaling in colorectal cancer.},
  author={Liang Qiao and Benjamin Chun-Yu Wong},
  journal={Carcinogenesis},
  year={2009},
  volume={30 12},
  pages={
          1979-86
        }
}
  • L. Qiao, B. Wong
  • Published 1 December 2009
  • Biology, Chemistry
  • Carcinogenesis
Notch signaling is an important molecular pathway involved in the determination of cell fate. In recent years, this signaling has been frequently reported to play a critical role in maintaining progenitor/stem cell population as well as a balance between cell proliferation, differentiation and apoptosis. Thus, Notch signaling may be mechanistically involved carcinogenesis. Indeed, many studies have showed that Notch signaling is overexpressed or constitutively activated in many cancers… 

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An overview of the activity of Notch signaling in a variety of tumors is provided, focusing mostly on its role in the maintenance of the undifferentiated subset of cancer cells.
Inflammation and Notch signaling: a crosstalk with opposite effects on tumorigenesis
TLDR
The hypothesis that specific inflammatory conditions can control the activation of the Notch pathway in terms of biological effect is analyzed, partially explaining the dichotomy of both phenomena.
Notch1-dependent regulation of p27 determines cell fate in colorectal cancer.
TLDR
It is demonstrated that in colorectal carcinoma cells the Notch1-dependent activation of cell cycle and proliferation is mediated by repression of the cyclin-dependent kinase inhibitor (CDKI) p27, and the half-life of p27 significantly increased after siRNA‑mediated knockdown of notch1.
Notch signaling pathway: architecture, disease, and therapeutics
TLDR
This review focuses on both classical and the latest findings related to NOTCH signaling to illustrate the history, architecture, regulatory mechanisms, contributions to physiological development, related diseases, and therapeutic applications of the NOTCH pathway.
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This review highlights recent findings regarding the molecular and functional aspects of Notch-mediated neoplastic transformation and cellular mechanisms that potentially explain the complex role of notch in tumorigenesis.
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