Role of Notch signal transduction in Kaposi's sarcoma-associated herpesvirus gene expression.

@article{Chang2005RoleON,
  title={Role of Notch signal transduction in Kaposi's sarcoma-associated herpesvirus gene expression.},
  author={Heesoon Chang and Dirk P. Dittmer and Young C Shin and Youngkwon Hong and Jae U Jung},
  journal={Journal of virology},
  year={2005},
  volume={79 22},
  pages={14371-82}
}
Kaposi's sarcoma-associated herpesvirus (KSHV) RTA transcription factor is recruited to its responsive elements through interaction with a Notch-mediated transcription factor, RBP-Jkappa, indicating that RTA mimics cellular Notch signal transduction to activate viral lytic gene expression. To test whether cellular Notch signal transduction and RTA are functionally exchangeable for viral gene expression, human Notch intracellular (hNIC) domain that constitutively activates RBP-Jkappa… CONTINUE READING

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