Role of Non-coding RNAs in chemotherapeutic treatments

@inproceedings{Vannini2015RoleON,
  title={Role of Non-coding RNAs in chemotherapeutic treatments},
  author={Ivan Vannini},
  year={2015}
}
The transcribed ultraconserved regions (T-UCRs) are a group of long non-coding RNAs involved in human carcinogenesis. The factors regulating the expression of T-UCRs and their mechanism of action in human cancers are unknown. In this work it was shown that high expression of uc.339 associates with lower survival in 204 non-small cell lung cancer (NSCLC) patients. Moreover, it was shown that uc.339 found up-regulated in archival NSCLC samples, acts as a decoy RNA for miR-339-3p, -663-3p and -95… 
View via Publisher
amsdottorato.unibo.it

Tables from this paper

References

SHOWING 1-10 OF 46 REFERENCES
An integrative genomics screen uncovers ncRNA T-UCR functions in neuroblastoma tumours
TLDR
For the first time, a T-UCR expression landscape in neuroblastoma is defined and widespread T- UCR involvement in diverse cellular processes that are deregulated in the process of tumourigenesis is suggested.
Expression and functional role of a transcribed noncoding RNA with an ultraconserved element in hepatocellular carcinoma
TLDR
A critical role is identified for TUC338 in regulation of transformed cell growth and of transcribed ultraconserved ncRNA as a unique class of genes involved in the pathobiology of HCC.
Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas.
Expression Levels of Transcribed Ultraconserved Regions uc.73 and uc.388 Are Altered in Colorectal Cancer
TLDR
Preliminary results suggest that Uc.73 and uc.388 could be potential diagnostic and prognostic biomarkers in CRC patients.
MicroRNA-95 promotes cell proliferation and targets sorting Nexin 1 in human colorectal carcinoma.
TLDR
It is demonstrated that miR-95 increases proliferation by directly targeting SNX1, defining mi R-95 as a new oncogenic miRNA in CRC.
Regulation of pri-miRNA processing by a long noncoding RNA transcribed from an ultraconserved region.
CpG island hypermethylation-associated silencing of non-coding RNAs transcribed from ultraconserved regions in human cancer
TLDR
The finding that, in addition to microRNAs, another class of ncRNAs (T-UCRs) undergoes DNA methylation-associated inactivation in transformed cells supports a model in which epigenetic and genetic alterations in coding and non-coding sequences cooperate in human tumorigenesis.
miRNA-95 mediates radioresistance in tumors by targeting the sphingolipid phosphatase SGPP1.
TLDR
Next-generation sequencing and combined in silico prediction and microarray expression analyses identify and validated the sphingolipid phosphatase SGPP1, an antagonist of sphingosine-1-phosphate signaling, as a target of miR-95 that promotes radiation resistance.
MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B
TLDR
The enforced expression of miR-29s in lung cancer cell lines restores normal patterns of DNA methylation, induces reexpression of methylation-silenced tumor suppressor genes, and inhibits tumorigenicity in vitro and in vivo.
Extracellular Vesicle-Mediated Transfer of a Novel Long Noncoding RNA TUC339: A Mechanism of Intercellular Signaling in Human Hepatocellular Cancer.
TLDR
Findings expand the potential roles of ucRNA in HCC, support the existence of selective mechanisms for lncRNA export from cells, and implicate extracellular vesicle-mediated transfer of lnc RNA as a mechanism by which tumor cells can modulate their local cellular environment.
...
...