Role of Nogo-A in neuronal survival in the reperfused ischemic brain.

@article{Kilic2010RoleON,
  title={Role of Nogo-A in neuronal survival in the reperfused ischemic brain.},
  author={Ertugrul Kilic and Ayman ElAli and Ulkan Kilic and Zeyun Guo and Milas Ugur and Unal Uslu and Claudio L A Bassetti and Martin E. Schwab and Dirk M. Hermann},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2010},
  volume={30 5},
  pages={
          969-84
        }
}
Nogo-A is an oligodendroglial neurite outgrowth inhibitor, the deactivation of which enhances brain plasticity and functional recovery in animal models of stroke. Nogo-A's role in the reperfused brain tissue was still unknown. By using Nogo-A(-/-) mice and mice in which Nogo-A was blocked with a neutralizing antibody (11C7) that was infused into the lateral ventricle or striatum, we show that Nogo-A inhibition goes along with decreased neuronal survival and more protracted neurologic recovery… CONTINUE READING

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