Role of Neuroactive Steroid Allopregnanolone in Antipsychotic-like Action of Olanzapine in Rodents

@article{Ugale2004RoleON,
  title={Role of Neuroactive Steroid Allopregnanolone in Antipsychotic-like Action of Olanzapine in Rodents},
  author={Rajesh Ramesh Ugale and Khemraj Hirani and Micaela Morelli and Chandrabhan Tukaram Chopde},
  journal={Neuropsychopharmacology},
  year={2004},
  volume={29},
  pages={1597-1609}
}
Olanzapine increases brain allopregnanolone (ALLO) levels sufficiently to modulate neuronal activity by allosterically regulating GABAA receptors. Recently, we reported the antipsychotic-like profile of ALLO in rodents. The present study examined the hypothesis that olanzapine-induced elevation of endogenous neurosteroid ALLO is vital for its neuroleptic-like action. The conditioned avoidance response (CAR) and apomorphine-induced climbing behavioral paradigms were used in rodents… CONTINUE READING
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