Role of Na+-H+ antiport in rat proximal tubule NaCl absorption.

Abstract

We recently showed that, in the presence of physiological sodium concentrations, 4.3 mM luminal amiloride inhibits 90% of apical membrane Na+-H+ antiporter activity in the in vivo microperfused rat proximal convoluted tubule. In the present studies we examined the effect of 4.3 mM luminal amiloride on transepithelial NaCl absorption from a high-chloride… (More)

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