Role of Na+-H+ and Na+-Ca2+ exchange in hypoxia-related acute astrocyte death.

@article{Bondarenko2005RoleON,
  title={Role of Na+-H+ and Na+-Ca2+ exchange in hypoxia-related acute astrocyte death.},
  author={Alexander Bondarenko and Nataliya Svichar and Mitchell Chesler},
  journal={Glia},
  year={2005},
  volume={49 1},
  pages={143-52}
}
Cultured astrocytes do not succumb to hypoxia/zero glucose for up to 24 h, yet astrocyte death following injury can occur within 1 h. It was previously demonstrated that astrocyte loss can occur quickly when the gaseous and interstitial ionic changes of transient brain ischemia are simulated: After a 20-40-min exposure to hypoxic, acidic, ion-shifted Ringer (HAIR), most cells died within 30 min after return to normal saline (i.e., "reperfusion"). Astrocyte death required external Ca2+ and was… CONTINUE READING

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