Role of Na(+)HCO(3)(-) cotransporter NBC1, Na(+)/H(+) exchanger NHE1, and carbonic anhydrase in rabbit duodenal bicarbonate secretion.

@article{Jacob2000RoleON,
  title={Role of Na(+)HCO(3)(-) cotransporter NBC1, Na(+)/H(+) exchanger NHE1, and carbonic anhydrase in rabbit duodenal bicarbonate secretion.},
  author={Petra Jacob and Stephanie Christiani and Heidi Rossmann and Georg Lamprecht and D. Vieillard-Baron and Rolf M{\"u}ller and Michael Gregor and Ursula Seidler},
  journal={Gastroenterology},
  year={2000},
  volume={119 2},
  pages={406-19}
}
BACKGROUND & AIMS HCO(3)(-) supply to the enterocyte is rate limiting for duodenal HCO(3)(-) secretion (J(HCO3-)). This study defines the molecular nature of the major HCO(3)(-) uptake pathways in rabbit duodenocytes and investigates their physiologic significance and regulation during basal and stimulated J(HCO3-). METHODS & RESULTS pH gradient-driven (22)Na(+) uptake into duodenal basolateral membrane vesicles was partly HCO(3)(-) dependent, stilbene sensitive, and therefore mediated by Na… CONTINUE READING
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