Role of Na(+)-Ca2+ exchange in the regulation of vascular smooth muscle tension.

@article{Motley1993RoleON,
  title={Role of Na(+)-Ca2+ exchange in the regulation of vascular smooth muscle tension.},
  author={E D Motley and Richard J. Paul and Mohammed A Matlib},
  journal={The American journal of physiology},
  year={1993},
  volume={264 4 Pt 2},
  pages={H1028-40}
}
To determine the role of the Na(+)-Ca2+ exchange systems of nerve terminal and sarcolemmal membrane on development of tension in rabbit aortic rings, internal or external Na+ concentration was changed with either ouabain or Na(+)-free solution, respectively. Ouabain produced a verapamil-insensitive but external Na(+)- and Ca(2+)-dependent biphasic tension with distinct lag periods both of which were shortened by depolarization with KCl. The first phase of tension was inhibited by prazosin… CONTINUE READING
10 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

Similar Papers

Loading similar papers…