Role of NRF2 in protection against hyperoxic lung injury in mice.

  title={Role of NRF2 in protection against hyperoxic lung injury in mice.},
  author={H Cho and Anne E. Jedlicka and Sekhar P. M. Reddy and Thomas Wells Kensler and Masayuki Yamamoto and Liu-yi Zhang and Steven R. Kleeberger},
  journal={American journal of respiratory cell and molecular biology},
  volume={26 2},
NRF2 is a transcription factor important in the protection against carcinogenesis and oxidative stress through antioxidant response element (ARE)-mediated transcriptional activation of several phase 2 detoxifying and antioxidant enzymes. This study was designed to determine the role of NRF2 in the pathogenesis of hyperoxic lung injury by comparing pulmonary responses to 95-98% oxygen between mice with site-directed mutation of the gene for NRF2 (Nrf2-/-) and wild-type mice (Nrf2+/+). Pulmonary… CONTINUE READING
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