Role of NRAS mutations as prognostic and predictive markers in metastatic colorectal cancer.

Abstract

NRAS mutations occur in 3-5% of colorectal cancer. Differently from KRAS and BRAF mutations, the role of NRAS mutations as prognostic and predictive markers in metastatic colorectal cancer (mCRC) has been investigated to a lesser extent. A retrospective series suggested the role of NRAS mutations as predictors of resistance to anti-EGFR monoclonal… (More)
DOI: 10.1002/ijc.28955

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@article{Schirripa2015RoleON, title={Role of NRAS mutations as prognostic and predictive markers in metastatic colorectal cancer.}, author={Marta Schirripa and Chiara Cremolini and Fotios Loupakis and Manfredi Morvillo and Francesca Bergamo and Federica Zoratto and Lisa Salvatore and Carlotta Antoniotti and Federica Marmorino and Elisa Sensi and Cristiana Lupi and Gabriella Fontanini and Veronica De Gregorio and Riccardo Giannini and Fulvio Basolo and Gianluca Masi and Alfredo Falcone}, journal={International journal of cancer}, year={2015}, volume={136 1}, pages={83-90} }