Role of NOX2 in the regulation of afferent arteriole responsiveness.

@article{Carlstrm2009RoleON,
  title={Role of NOX2 in the regulation of afferent arteriole responsiveness.},
  author={Mattias Carlstr{\"o}m and En Yin Lai and Zufu Ma and Andreas Patzak and Russell D. Brown and Anders Erik Gosta Persson},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2009},
  volume={296 1},
  pages={R72-9}
}
NADPH oxidases (NOX) are the major source of reactive oxygen species (ROS) in the vasculature and contribute to the control of renal perfusion. The role of NOX2 in the regulation of blood pressure and afferent arteriole responsiveness was investigated in NOX2(-/-) and wild-type mice. Arteriole constrictions to ANG II (10(-14)-10(-6) mol/l) were weaker in NOX2(-/-) compared with wild types. N(omega)-nitro-l-arginine methyl ester (l-NAME; 10(-4) mol/l) treatment reduced basal diameters… CONTINUE READING
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