Role of NO in cyclosporin nephrotoxicity: effects of chronic NO inhibition and NO synthases gene expression.

@article{Bobadilla1998RoleON,
  title={Role of NO in cyclosporin nephrotoxicity: effects of chronic NO inhibition and NO synthases gene expression.},
  author={Norma A Bobadilla and Gerardo Gamba and Edilia Tapia and Romeo Garc{\'i}a-Torres and Alexis Bolio and Pedro L{\'o}pez-Zetina and Jaime Herrera-Acosta},
  journal={American journal of physiology. Renal physiology},
  year={1998},
  volume={274 4},
  pages={F791-F798}
}
The role of nitric oxide (NO) during cyclosporin renal vasoconstriction was evaluated by glomerular hemodynamic and histological changes produced by chronic NO synthesis inhibition and neuronal (nNOS), inducible (iNOS), and endothelial (eNOS) NO synthases mRNA expression in renal cortex and medulla. Uninephrectomized rats treated during 7 days with vehicle (Veh), cyclosporin A (CsA) 30 mg/kg, CsA + nitro-l-arginine methyl ester (l-NAME), and Veh +l-NAME (10 mg/dl) in the drinking water were… CONTINUE READING

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