Role of NMDA receptor–dependent activation of SREBP1 in excitotoxic and ischemic neuronal injuries

@article{Taghibiglou2009RoleON,
  title={Role of NMDA receptor–dependent activation of SREBP1 in excitotoxic and ischemic neuronal injuries},
  author={Changiz Taghibiglou and Henry G. S. Martin and Ted Weita Lai and Taesup Cho and Shiv Prasad and Luba Kojic and Jie Lu and Yitao Liu and Edmund Lo and Shuhong Zhang and Julia Z Z Wu and Yu Ping Li and Yan Hua Wen and Joon-Hyuk Imm and Max S. Cynader and Yu Tian Wang},
  journal={Nature Medicine},
  year={2009},
  volume={15},
  pages={1399-1406}
}
Excitotoxic neuronal damage caused by overactivation of N-methyl-D-aspartate glutamate receptors (NMDARs) is thought to be a principal cause of neuronal loss after stroke and brain trauma. Here we report that activation of sterol regulatory element binding protein-1 (SREBP-1) transcription factor in affected neurons is an essential step in NMDAR-mediated excitotoxic neuronal death in both in vitro and in vivo models of stroke. The NMDAR-mediated activation of SREBP-1 is a result of increased… CONTINUE READING

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Essential role of SBP-1 activation in oxygen deprivation induced lipid accumulation and increase in body width/length ratio in Caenorhabditis elegans

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