Role of NMDA Receptors in Dopamine Neurons for Plasticity and Addictive Behaviors

@article{Zweifel2008RoleON,
  title={Role of NMDA Receptors in Dopamine Neurons for Plasticity and Addictive Behaviors},
  author={Larry S Zweifel and Emanuela Argilli and Antonello Bonci and Richard D Palmiter},
  journal={Neuron},
  year={2008},
  volume={59},
  pages={486-496}
}
A single exposure to drugs of abuse produces an NMDA receptor (NMDAR)-dependent long-term potentiation (LTP) of AMPA receptor (AMPAR) currents in DA neurons; however, the importance of LTP for various aspects of drug addiction is unclear. To test the role of NMDAR-dependent plasticity in addictive behavior, we genetically inactivated functional NMDAR signaling exclusively in DA neurons (KO mice). Inactivation of NMDARs results in increased AMPAR-mediated transmission that is indistinguishable… CONTINUE READING
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