Role of NMDA Receptor Subtypes in Governing the Direction of Hippocampal Synaptic Plasticity

@article{Liu2004RoleON,
  title={Role of NMDA Receptor Subtypes in Governing the Direction of Hippocampal Synaptic Plasticity},
  author={Lidong Liu and T. Wong and M. Pozza and K. Lingenhoehl and Yushan Wang and M. Sheng and Y. Auberson and Y. Wang},
  journal={Science},
  year={2004},
  volume={304},
  pages={1021 - 1024}
}
Activation of N-methyl-d-aspartate subtype glutamate receptors (NMDARs) is required for long-term potentiation (LTP) and long-term depression (LTD) of excitatory synaptic transmission at hippocampal CA1 synapses, the proposed cellular substrates of learning and memory. However, little is known about how activation of NMDARs leads to these two opposing forms of synaptic plasticity. Using hippocampal slice preparations, we showed that selectively blocking NMDARs that contain the NR2B subunit… Expand
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