Role of NK cells in tumour growth and metastasis in beige mice

  title={Role of NK cells in tumour growth and metastasis in beige mice},
  author={James E Talmadge and Kenneth M. Meyers and David J. Prieur and Jean R. Starkey},
Although natural killer (NK) cells are thought to give the host a spontaneous resistance against tumours and have been postulated to act in vivo as surveillor cells1, definitive data in support of these hypotheses has not been obtained. Recently the beige (bg) mouse, a morphological homologue of the human Chediak–Higashi (CH) syndrome2–4, was shown to be deficient in NK activity5. Specifically, spleen cells of bg mice were demonstrated to be incapable of in vitro natural cytotoxicity against… CONTINUE READING

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