Role of NF-kappaB-mediated interleukin-8 expression in intraocular neovascularization.

  title={Role of NF-kappaB-mediated interleukin-8 expression in intraocular neovascularization.},
  author={Akihiro Yoshida and Shoko Yoshida and Ahmad K. Khalil and Teruo Ishibashi and Hidetoshi Inomata},
  journal={Investigative ophthalmology & visual science},
  volume={39 7},
PURPOSE To investigate the role of interleukin (IL)-8 in intraocular neovascularization and the mechanism of its production. METHODS Interleukin-8 was measured with enzyme-linked immunosorbent assays in vitreous and aqueous fluid obtained from patients with neovascular diseases. Localization of IL-8 was examined by immunohistochemistry. An in vitro angiogenesis assay was performed on collagen gels, by using bovine aortic endothelial cells to determine the effect of the vitreous fluid. In… CONTINUE READING


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