Role of NF-kappaB in flow-induced vascular remodeling.

  title={Role of NF-kappaB in flow-induced vascular remodeling.},
  author={Yves Castier and Bhama Ramkhelawon and St{\'e}phanie Riou and Alain Tedgui and St{\'e}phanie Lehoux},
  journal={Antioxidants & redox signaling},
  volume={11 7},
Vascular remodeling associated with increased blood flow involves reactive oxygen species (ROS)-dependent activation of matrix metalloproteinases (MMPs). To investigate the potential role of NF-kappaB in this process, human umbilical vein endothelial cells were subjected to different flow conditions during a 24-h period. Normal (15 dynes/cm(2)) and high (30 dynes/cm(2)) shear stress induced IkappaBalpha degradation and NF-kappaB p65 phosphorylation, and activated MMP-2 and MMP-9. These effects… CONTINUE READING
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