Role of NF-kappaB and myc proteins in apoptosis induced by hepatitis B virus HBx protein.

@article{Su2001RoleON,
  title={Role of NF-kappaB and myc proteins in apoptosis induced by hepatitis B virus HBx protein.},
  author={Fei Su and Christian Theodosis and Robert J Schneider},
  journal={Journal of virology},
  year={2001},
  volume={75 1},
  pages={215-25}
}
Chronic infection with hepatitis B virus (HBV) promotes a high level of liver disease and cancer in humans. The HBV HBx gene encodes a small regulatory protein that is essential for viral replication and is suspected to play a role in viral pathogenesis. HBx stimulates cytoplasmic signal transduction pathways, moderately stimulates a number of transcription factors, including several nuclear factors, and in certain settings sensitizes cells to apoptosis by proapoptotic stimuli, including tumor… CONTINUE READING