Role of NADase in virulence in experimental invasive group A streptococcal infection.

@article{Bricker2005RoleON,
  title={Role of NADase in virulence in experimental invasive group A streptococcal infection.},
  author={Angela L Bricker and Vincent J. Carey and Michael R. Wessels},
  journal={Infection and immunity},
  year={2005},
  volume={73 10},
  pages={6562-6}
}
Group A streptococci (GAS) produce several exoproteins that are thought to contribute to the pathogenesis of human infection. Two such proteins, streptolysin O (SLO) and NAD(+)-glycohydrolase (NADase), have been shown to interact functionally as a compound signaling toxin. When GAS are bound to the surface of epithelial cells in vitro, SLO forms pores in the cell membrane and delivers NADase to the epithelial cell cytoplasm. In vitro, intoxication of keratinocytes with NADase is associated with… CONTINUE READING
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