Corpus ID: 32264217

Role of NADH shuttles in glucose-induced insulin secretion from fetal beta-cells.

@article{Tan2002RoleON,
  title={Role of NADH shuttles in glucose-induced insulin secretion from fetal beta-cells.},
  author={Cynthia Tan and Bernard E Tuch and Jian Tu and Shane A. Brown},
  journal={Diabetes},
  year={2002},
  volume={51 10},
  pages={
          2989-96
        }
}
  • Cynthia Tan, Bernard E Tuch, +1 author Shane A. Brown
  • Published in Diabetes 2002
  • Medicine
  • The NADH shuttle system, which transports the substrate for oxidative metabolism directly from the cytosol to the mitochondrial electron transport chain, has been shown to be essential for glucose-induced activation of mitochondrial metabolism and insulin secretion in adult beta-cells. We examined the role of these shuttles in the fetal beta-cell, which is immature in being unable to secrete insulin in response to glucose. The activity and concentration of the two key enzymes of the NADH… CONTINUE READING

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