Role of NADH: quinone oxidoreductase-1 in the tight junctions of colonic epithelial cells

@inproceedings{Nam2014RoleON,
  title={Role of NADH: quinone oxidoreductase-1 in the tight junctions of colonic epithelial cells},
  author={Seung Taek Nam and Jung Hwan Hwang and Dae Hong Kim and Mi Jung Park and Ik Hwan Lee and Hyo Jung Nam and Jin Ku Kang and Sung Kuk Kim and Jae Sam Hwang and Hyo Kyun Chung and Minho Shong and Chul-Ho Lee and Ho Kim},
  booktitle={BMB reports},
  year={2014}
}
NADH:quinone oxidoreductase 1 (NQO1) is known to be involved in the regulation of energy synthesis and metabolism, and the functional studies of NQO1 have largely focused on metabolic disorders. Here, we show for the first time that compared to NQO1-WT mice, NQO1-KO mice exhibited a marked increase of permeability and spontaneous inflammation in the gut. In the DSS-induced colitis model, NQO1-KO mice showed more severe inflammatory responses than NQO1-WT mice. Interestingly, the transcript… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 27 REFERENCES

Pathophysiological role of Toll-like receptor 5 engagement by bacterial flagellin in colonic inflammation.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2005
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Regulation of genes encoding NAD(P)H:quinone oxidoreductases.

  • Free radical biology & medicine
  • 2000
VIEW 9 EXCERPTS
HIGHLY INFLUENTIAL

A NAD(P)H:quinone oxidoreductase 1 polymorphism is a risk factor for human colon cancer.

  • Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • 2006
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Enteral feeding decreases gut apoptosis, permeability, and lung inflammation during murine endotoxemia.

  • American journal of physiology. Gastrointestinal and liver physiology
  • 2001
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL