Role of NAD(P)H oxidase in the regulation of cardiac L-type Ca2+ channel function during acute hypoxia.

@article{Hool2005RoleON,
  title={Role of NAD(P)H oxidase in the regulation of cardiac L-type Ca2+ channel function during acute hypoxia.},
  author={Livia C. Hool and Carla A Di Maria and Helena M. Viola and Peter G Arthur},
  journal={Cardiovascular research},
  year={2005},
  volume={67 4},
  pages={
          624-35
        }
}
OBJECTIVE The role of NAD(P)H oxidase in regulating cellular production of reactive oxygen species (ROS) and the L-type Ca2+ channel during acute hypoxia was examined in adult ventricular myocytes from guinea pig. METHODS The fluorescent indicator dihydroethidium (DHE) was used to detect superoxide and the response of the L-type Ca2+ channel to beta-adrenergic receptor stimulation was used as a functional reporter since hypoxia increases the sensitivity of the L-type Ca2+ channel (I(Ca-L)) to… CONTINUE READING

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