Role of NAD(P)H:quinone oxidoreductase 1 in clofibrate-mediated hepatoprotection from acetaminophen.

@article{Moffit2007RoleON,
  title={Role of NAD(P)H:quinone oxidoreductase 1 in clofibrate-mediated hepatoprotection from acetaminophen.},
  author={Jeffrey S Moffit and Lauren M. Aleksunes and Michael J Kardas and Angela M Lucas Slitt and Curtis D. Klaassen and Jos{\'e} Enrique Manautou},
  journal={Toxicology},
  year={2007},
  volume={230 2-3},
  pages={197-206}
}
Mice pretreated with the peroxisome proliferator clofibrate (CFB) are resistant to acetaminophen (APAP) hepatotoxicity. Whereas the mechanism of protection is not entirely known, CFB decreases protein adducts formed by the reactive metabolite of APAP, N-acetyl-p-benzoquinone imine (NAPQI). NAD(P)H:quinone oxidoreductase 1 (NQO1) is an enzyme with antioxidant properties that is responsible for the reduction of cellular quinones. We hypothesized that CFB increases NQO1 activity, which in turn… CONTINUE READING
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