Role of N-terminus of tyrosine hydroxylase in the biosynthesis of catecholamines

@article{Nakashima2009RoleON,
  title={Role of N-terminus of tyrosine hydroxylase in the biosynthesis of catecholamines},
  author={Akira Nakashima and Nobuhiro Hayashi and Yoko S. Kaneko and Keiji Mori and Esther L. Sabban and Toshiharu Nagatsu and Akira Ota},
  journal={Journal of Neural Transmission},
  year={2009},
  volume={116},
  pages={1355-1362}
}
Tyrosine hydroxylase (TH) catalyzes the conversion of l-tyrosine to l-dopa, which is the initial and rate-limiting step in the biosynthesis of catecholamines [CA; dopamine (DA), noradrenaline, and adrenaline], and plays a central role in the neurotransmission and hormonal actions of CA. Thus, TH is related to various neuro-psychiatric diseases such as TH deficiency, Parkinson’s disease (PD), and schizophrenia. Four isoforms of human TH (hTH1–hTH4) are produced from a single gene by alternative… 
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The quaternary structure of human tyrosine hydroxylase: effects of dystonia‐associated missense variants on oligomeric state and enzyme activity
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