Role of N-terminal amino acids in the absorption-enhancing effects of the c-terminal fragment of Clostridium perfringens enterotoxin.

@article{Masuyama2005RoleON,
  title={Role of N-terminal amino acids in the absorption-enhancing effects of the c-terminal fragment of Clostridium perfringens enterotoxin.},
  author={Akane Masuyama and Masuo Kondoh and Hirotoshi Seguchi and Azusa Takahashi and Motoki Harada and Makiko Fujii and Hiroyuki Mizuguchi and Yasuhiko Horiguchi and Yoshiteru Watanabe},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2005},
  volume={314 2},
  pages={
          789-95
        }
}
We recently found that a polypeptide, the C-terminal of Clostridium perfringens enterotoxin (C-CPE), was a novel type of drug absorption enhancer. The C-terminal of C-CPE is thought to play a role in the binding of C-CPE to its receptor, claudin-4; however, the function of the N-terminal of C-CPE is unclear. In the present study, we evaluated the role of the N-terminal domain of C-CPE in jejunal absorption and claudin-4 binding. The treatment of rat jejunum with C-CPE resulted in enhanced… CONTINUE READING

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