Role of N-cadherin in the sorting-out of mesenchymal cells and in the positional identity along the proximodistal axis of the chick limb bud.

@article{Yajima1999RoleON,
  title={Role of N-cadherin in the sorting-out of mesenchymal cells and in the positional identity along the proximodistal axis of the chick limb bud.},
  author={Hiroshi Yajima and S Yoneitamura and Naoyuki Watanabe and Koji Tamura and Hiroyuki Ide},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={1999},
  volume={216 3},
  pages={274-84}
}
Mesenchymal cells from different stages of chick limb buds sort out in monolayer culture, suggesting the presence of different cell affinities dependent on their positions along the proximodistal axis. However, it is still not clear which molecules are responsible for the sorting-out. Here, we propose that N-cadherin, a cell-adhesion molecule, is involved in the sorting-out and is likely to be a component of the mechanism of proximodistal patterning in the developing limb. N-cadherin proteins… CONTINUE READING