Role of N-cadherin in Schwann cell precursors of growing nerves.

  title={Role of N-cadherin in Schwann cell precursors of growing nerves.},
  author={Ina B Wanner and Nicole K Guerra and James Mahoney and Aman Kumar and Patrick McGhee Wood and Rhona Mirsky and Kristj{\'a}n R. Jessen},
  volume={54 5},
In the present paper, we determine the localization and developmental regulation of N-cadherin in embryonic rat nerves and examine the role of N-cadherin in this system. We also identify a major transition in the architecture of embryonic nerves and relating it to N-cadherin expression. We find that in early embryonic nerves, N-cadherin is primarily expressed in Schwann cell precursors. Pronounced expression is seen at distal nerve fronts where these cells associate with growth cones, and the… CONTINUE READING


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