Role of Microscopic Flexibility in Tightly Curved DNA

  title={Role of
Microscopic Flexibility in Tightly Curved
  author={Maryna Taranova and Andrew D. Hirsh and Noel C. Perkins and Ioan Andricioaei},
  booktitle={The journal of physical chemistry. B},
The genetic material in living cells is organized into complex structures in which DNA is subjected to substantial contortions. Here we investigate the difference in structure, dynamics, and flexibility between two topological states of a short (107 base pair) DNA sequence in a linear form and a covalently closed, tightly curved circular DNA form. By employing a combination of all-atom molecular dynamics (MD) simulations and elastic rod modeling of DNA, which allows capturing microscopic… CONTINUE READING