Role of Metastasis-Related Genes in Cisplatin Chemoresistance in Gastric Cancer

  title={Role of Metastasis-Related Genes in Cisplatin Chemoresistance in Gastric Cancer},
  author={Y. Nishiguchi and N. Oue and Rina Fujiwara-Tani and Takamitsu Sasaki and H. Ohmori and Shingo Kishi and Shiori Mori and T. Mori and N. Ikeda and S. Matsumoto and K. Wakatsuki and Y. Luo and W. Yasui and M. Sho and H. Kuniyasu},
  journal={International Journal of Molecular Sciences},
  • Y. Nishiguchi, N. Oue, +12 authors H. Kuniyasu
  • Published 2019
  • Medicine
  • International Journal of Molecular Sciences
  • The role of metastasis-related genes in cisplatin (CDDP) chemoresistance in gastric cancer is poorly understood. Here, we examined the expression of four metastasis-related genes (namely, c-met, HMGB1, RegIV, PCDHB9) in 39 cases of gastric cancer treated with neoadjuvant therapy with CDDP or CDDP+5-fluorouracil and evaluated its association with CDDP responsiveness. Comparison of CDDP-sensitive cases with CDDP-resistant cases, the expression of c-met, HMGB1, and PCDHB9 was correlated with CDDP… CONTINUE READING
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