Role of Mental Retardation-Associated Dystrophin-Gene Product Dp71 in Excitatory Synapse Organization, Synaptic Plasticity and Behavioral Functions

@inproceedings{Daoud2008RoleOM,
  title={Role of Mental Retardation-Associated Dystrophin-Gene Product Dp71 in Excitatory Synapse Organization, Synaptic Plasticity and Behavioral Functions},
  author={Fatma Daoud and Aurora Antonia Candelario-Mart{\'i}nez and Jean-Marie Billard and Avi Avital and Malik Khelfaoui and Yael Rozenvald and Maryvonne Gu{\'e}gan and Dominique Mornet and Danielle Jaillard and Uri Nudel and Jamel Chelly and Dalila Mart{\'i}nez-Rojas and Serge Laroche and David L. Yaffe and Cyrille Vaillend},
  booktitle={PloS one},
  year={2008}
}
BACKGROUND Duchenne muscular dystrophy (DMD) is caused by deficient expression of the cytoskeletal protein, dystrophin. One third of DMD patients also have mental retardation (MR), likely due to mutations preventing expression of dystrophin and other brain products of the DMD gene expressed from distinct internal promoters. Loss of Dp71, the major DMD-gene product in brain, is thought to contribute to the severity of MR; however, the specific function of Dp71 is poorly understood. METHODOLOGY… CONTINUE READING

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