Role of Membrane Microdomains in Compartmentation of cAMP Signaling

  title={Role of Membrane Microdomains in Compartmentation of cAMP Signaling},
  author={Shailesh Agarwal and Pei-Chi Yang and Monica Rice and Cherie A. Singer and Viacheslav O Nikolaev and Martin J. Lohse and Colleen E. Clancy and Robert D. Harvey},
  booktitle={PloS one},
Spatially restricting cAMP production to discrete subcellular locations permits selective regulation of specific functional responses. But exactly where and how cAMP signaling is confined is not fully understood. Different receptors and adenylyl cyclase isoforms responsible for cAMP production are not uniformly distributed between lipid raft and non-lipid raft domains of the plasma membrane. We sought to determine the role that these membrane domains play in organizing cAMP responses in HEK293… CONTINUE READING
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