Role of MUTYH in human cancer.

  title={Role of MUTYH in human cancer.},
  author={Filomena Mazzei and Alessandra Viel and Margherita Bignami},
  journal={Mutation research},
MUTYH, a human ortholog of MutY, is a post-replicative DNA glycosylase, highly conserved throughout evolution, involved in the correction of mismatches resulting from a faulty replication of the oxidized base 8-hydroxyguanine (8-oxodG). In particular removal of adenine from A:8-oxodG mispairs by MUTYH activity is followed by error-free base excision repair (BER) events, leading to the formation of C:8-oxodG base pairs. These are the substrate of another BER enzyme, the OGG1 DNA glycosylase… CONTINUE READING

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