Role of MUTYH in human cancer.

@article{Mazzei2013RoleOM,
  title={Role of MUTYH in human cancer.},
  author={Filomena Mazzei and Alessandra Viel and Margherita Bignami},
  journal={Mutation research},
  year={2013},
  volume={743-744},
  pages={33-43}
}
MUTYH, a human ortholog of MutY, is a post-replicative DNA glycosylase, highly conserved throughout evolution, involved in the correction of mismatches resulting from a faulty replication of the oxidized base 8-hydroxyguanine (8-oxodG). In particular removal of adenine from A:8-oxodG mispairs by MUTYH activity is followed by error-free base excision repair (BER) events, leading to the formation of C:8-oxodG base pairs. These are the substrate of another BER enzyme, the OGG1 DNA glycosylase… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
25 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 25 extracted citations

Similar Papers

Loading similar papers…