Role of MSK1 in the malignant phenotype of Ras-transformed mouse fibroblasts.

@article{PrezCadaha2011RoleOM,
  title={Role of MSK1 in the malignant phenotype of Ras-transformed mouse fibroblasts.},
  author={Beatriz P{\'e}rez-Cadah{\'i}a and Bojan Drobic and Paula S. Espino and Shihua He and Soma Mandal and Shannon Healy and James R. Davie},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 1},
  pages={42-9}
}
Activated by the RAS-MAPK signaling pathway, MSK1 is recruited to immediate-early gene (IEG) regulatory regions, where it phosphorylates histone H3 at Ser-10 or Ser-28. Chromatin remodelers and modifiers are then recruited by 14-3-3 proteins, readers of phosphoserine marks, leading to the occupancy of IEG promoters by the initiation-engaged form of RNA polymerase II and the onset of transcription. In this study, we show that this mechanism of IEG induction, initially elucidated in parental 10T1… CONTINUE READING
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