Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption.

@article{Yujiri1998RoleOM,
  title={Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption.},
  author={Toshiaki Yujiri and Susan Sather and Gary R. Fanger and Gary Leon Johnson},
  journal={Science},
  year={1998},
  volume={282 5395},
  pages={
          1911-4
        }
}
Targeted disruption of the gene encoding MEK kinase 1 (MEKK1), a mitogen-activated protein kinase (MAPK) kinase kinase, defined its function in the regulation of MAPK pathways and cell survival. MEKK1(-/-) embryonic stem cells from mice had lost or altered responses of the c-Jun amino-terminal kinase (JNK) to microtubule disruption and cold stress but activated JNK normally in response to heat shock, anisomycin, and ultraviolet irradiation. Activation of JNK was lost and that of extracellular… CONTINUE READING
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ERK 2 was immunoprecipitated from cell lysates wi th the C-14 antibody

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